Aim To investigate the correlation of plasma brain natriuretic,C-terminal portion of pro-vasopressin(Copeptin) and serum high sensitivity C-reactive protein in evaluating the prognosis of patients with acute coronary syndrome.Methods The levels of plasma brain natriuretic,Copeptin and high sensitivity C-reactive protein were measured in 30 patients with acute myocardial infarction(AMI),38 patients with unstable angina pectoris(UAP),and 20 controls.The numbers of impaired coronary arteries,left main coronary stenosis,Gensini scoring of coronary stenosis and the levels of plasma brain natriuretic,Copeptin and high sensitivity C-reactive protein were compared respectively.Results The levels of plasma brain natriuretic,Copeptin and high sensitivity C-reactive protein in group AMI and group UAP were significantly higher than those in the controls(P<0.01),the levels of them in group AMI were significantly higher than those in group UAP.There were obvious positive correlations in the levels of plasma brain natriuretic and Copeptin with impaired coronary arteries,left main coronary stenosis,and Gensini score;however,there were no correlations in the levels of serum high sensitivity C-reactive protein with them.Conclusions Plasma levels of plasma brain natriuretic,Copeptin and high sensitivity C-reactive protein correlates with coronary artery stenosis in patients with acute coronary syndrome.They are important clinical parameters to reflect the severity of myocardial necrosis.