Aim To observe the expression of histone deacetylase 2 (HDAC 2) in hypertrophic cardiocytes induced by angiotensinⅡ(AngⅡ). Methods The cultured cardiocytes were treated with AngⅡ of different concentrations to induce hypertrophy.The mRNA levels of HDAC 2 and β-myosin heavy chain(β-MHC) were exmained by reverse transcription-polymerase chain reaction.The protein expressions of HDAC 2 and c-fos were exmanined by immunohistochemistry method.The morphologic changes of cardiocytes were observed under the contrast phase microscope. Results Myocytes were cultured successfully.After stimulated by AngⅡ the myocytes were enlarged under the contrast phase microscope.With the increasing of AngⅡ concentrations(2×10^-6 mol/L,2×10^-7 mol/L and 2×10^-8 mol/L),the mRNA levels of HDAC 2 and β-MHC increased.The immunohistochemistry results showed that the protein expressions of HDAC 2 and c-fos also increased in the hypertrophic cardiocytes.The areas of the myocytes increased with different AngⅡ(P<0.05). Conclusions The expression of HDAC 2 increased in hypertrophic cardiocytes stimulated by AngⅡ. HDAC 2 may play a role in cardiocyte hypertrophy.