Aim To explore the effect of probucol,rosuvastatin and their combination on atherosclerosis and cardiac function in essential hypertensive patients.Methods A total of 178 essential hypertensive patients,were randomly assigned to rosuvastatin group(rosuvastatin,10 mg/d),probucol group(probucol,500 mg/d) and the combination group(rosuvastatin+probucol).All the patients were treated and followed up for 8 months.The changes of matrix metalloproteinase(MMP),tumor necrosis factor(TNF-α),atherosclerosis plaque of artery and cardiac function between baseline and the end of 8 months were analysed.Results At the end of 8 months,rosuvastatin group,probucol group and the combination group showed reductions in MMP,TNF-α,the intima media thickness(IMT) of the common carotid artery and the size of plaque in coronary artery(CS);and the combination group showed more reductions compared with rosuvastatin group and probucol group.Left ventricular ejection fraction(LVEF) increased from 60.2%±11.0%to 64.4%±12.5%(P<0.05) and left ventricular peak filling rate(LVPFR) increased from 1.78±0.39 to 2.89±0.67(P<0. 01) in the combination group.Conclusion The combined treatment with probucol and rosuvastatin yielded better results in the context of improving left ventricular function and showed favorable effects on atherosclerosis plaque of artery.