Aim To evaluate the effect of AngiotensinⅡon EMMPRIN expression in THP-1 macrophage and its potential mechanism. Methods Macrophages cell line was esteblished by induced THP-1 using PMA,and then the effect of AngⅡ on EMMPRIN expression on THP-1 macrophages was investigated. Results RT-PCR and Western Blot showed that AngⅡ upregulated EMMPRIN expression in a dose and time dependent manner.Either nuclear factor-κB inhibitor PDTC or P65 RNAi treatment can suppress the effect of angⅡon EMMPRIN. Conclusion AngⅡupregulates the expression of EMMPRIN.Nuclear factor-κB is the critical factor involving in the EMMPRIN upregulation induced by angⅡ.