力学环境与动脉粥样硬化斑块内血管新生
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教育部科学技术研究重点项目(104158)资助


Relationship Between Blood Pressure and Carotid Haemodynamics in Normotensive Carotid Stenosis Patients
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    摘要:

    血管新生是指在原来存在的血管结构上长出新血管的生物学过程。急性冠状动脉综合征(ACS)主要为斑块破裂和血栓形成所引起,斑块内血管新生是斑块破裂的一个重要危险因素。而力学微环境与血管新生及微血管破裂关系密切,现阐述力学环境与斑块内血管新生的关系。①血管新生的力学微环境。动脉粥样硬化斑块因血管平滑肌细胞大量增殖和胶原大量沉积,引起微血管内腔压力增加,包括外膜的血管网所受压力上升,血管网血流压力梯度增强,局部....

    Abstract:

    Aim To explore the relationship between blood pressure and carotid haemodynamics in normotensive carotid stenosis patients by color duplex ultrasonography. Methods The 80 mortotensive carotid stenosis patients were checked for the blood pressure and carotid haemodynamics indexes,including systolic blood pressure(SBP),diastolic blood pressure(DBP) and the haemodynamics premeters of blilateral carotid arteries. Results The stenosis grades would accelerate blood velocity of the stenosis internal carotid artery.The vertebral artery blood flow velocity were faster in SBP of 90 to 120 mmHg and DBP of 60 to 79 mmHg,while the blood flow resistance was smaller in the same blood pressure level.Then the vertebral artery blood flow velocity would go down and the blood flow resistanc would raise,with the increase of blood pressure especially SBP of >120 mmHg,DBP of ≥80 mmHg. Conclusion Lowering blood pressure could help promoting the carotid blood flow velocity and increasing cerebral blood flow.And SBP of 90 to 120 mmHg and DBP of 60 to 79 mmHg may help maintaining the better cerebral haemodynamics.

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邱菊辉,王贵学,刘华.力学环境与动脉粥样硬化斑块内血管新生[J].中国动脉硬化杂志,2009,17(7):622.

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  • 收稿日期:2009-02-17
  • 最后修改日期:2009-06-11
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