Aim To explore the relationship of common carotid intima-media thickness(CIMT)and the coronary lesions' morphology with the thrombolysis in myocardial infarction(TIMI) risk score for non-ST-elevation acute coronary syndrome(NSTEACS). And evaluate the roles of CIMT in risk stratification of NSTEACS. Methods One hundred and thirty-two patients with NSTEACS were recruited.CIMT were measured,and the coronary angiographies were analysed to detect the single or multiple complex coronary stenostic lesions.Their correlation with TIMI risk score and its variables were investigated. Results Satisfying images of CIMT were obtained in one hundred and twenty-three patients(99.2%),and the general CIMT was 0.83±0.22 mm.Sixty-two patients(50.4%) had an abnormal(≥0.8 mm) CIMT,whilst 52 patients(39.4%) only had single complex coronary lesions and 80(60.6%) had multiple complex coronary lesions.In patients with abnormal CIMT,more of them were ≥65 years old,had diabetes,or with previous ischemic heart disease,than in those without abnormal CIMT;In patients with multiple complex coronary lesions,more of them were ≥65 years old,had diabetes,or with previous ischemic heart disease,than in those with single complex coronary lesions.CIMT was correlated with TIMI risk score(r=0.25,P=0.004),whilst the presence with multiple complex lesions was associated with TIMI risk scale(r=0.31,P<0.01).Using a Logistic regression analysis,the presence of an abnormal CIMT was only related to age ≥65 [OR: 3.52(CI: 1.48～9.37),P=0.001] and diabetes mellitus [OR: 3.83(CI: 1.66～8.91),P=0.004].The presence with multiple complex lesions was also associated with age ≥65 [OR: 17.32(CI: 6.53～52.34),P<0.001] and diabetes mellitus[OR: 3.06(CI: 1.84～8.73),P=0.006]. Conclusion CIMT and the presence of multiple complex lesions in patients with NSTEACS are correlated with TIMI risk score.Both variables were related to age and diabetes.CIMT can play a role in the risk stratification of NSTEACS.