Aim To discuss the relationship between bone minerals density (BMD) and carotid intima-media thickness (IMT) of postmenopausal patients with type 2 diabetes (T2DM).Methods 93 cases of postmenopausal patients with T2DM and 55 cases of control group were recruited.BMD on lumbar spine L1～4 and left femoral neck BMD were measured,and T2DM patients were divided into concurrent osteoporosis group (OP group) and non osteoporosis group (NOP group) according to BMD,with measuring carotid IMT,and collecting patients' age,duration of menopause and BMI etc.Results Comparing OP group with NOP group,the difference between age,duration of menopause,course of disease and BMI had statistical significance (P<0.01);compared with NOP group and control group,in OP group lumbar spine L1～4 and left femoral neck BMD decreased (P<0.01),carotid IMT thickens (P<0.01) and the plaque occurrence rate increased (P<0.05).Relative analysis showed that the lumbar spine L1～4 and left femoral neck BMD of T2DM group had negative correlation with age,duration of menopause,course of disease and carotid IMT,and positive correlation with BMI.Conclusion The BMD of postmenopausal patients with T2DM has certain relationship with carotid IMT.The postmenopausal patients with T2DM whose BMD is low are more susceptible to atherosclerosis.