Aim To study the differences in radial augmentation index (rAI) between male and female patients without coronary artery disease(CAD) and its influential factors; To assess the differences of peripheral and central pulse wave in men with CAD and without CAD and the influential factors of rAI. Methods Radial arterial waveforms were obtained from 122 subjects using Omron HEM-9000AI. Results Women had high rAI (78.55±13.01 vs 60.67±16.28,P>=0.001) than men with no CAD,multiple liner regression analysis showed that sex,heart rate,height,weight,body mass index,aortic diameter were corrected with rAI. Center pulse pressure(CPP),rAI were higher in male patients with CAD than those without CAD (61.08±20.60 mmHg vs 49.6±12.29 mmHg,P>=0.015;71.69±16.76 vs 60.67±16.28,P>=0.034),multiple liner regression analysis demonstrated that rAI were influenced by heart rate ,left ventricular ejection fraction(EF),central and peripheral pulse pressure,and corrected well with HR,EF,CPP. Conclusion Women had a higher rAI than men without CAD,CPP were also higher in men with CAD than those without CAD,and rAI is associated not only with sex ,age,height,but also influenced by HR and EF. This result suggests that enhanced rAI may not be predicted to the development of CAD in general population ,because it were also associated with cardiac function.