Aim To investigate the relation between the polymorphisms of angiotensinogen(AGT) genetpye M235T and angiotensin-converting enzyme(ACE) genetpye I/D and coronary atherosclerosis. Methods The study population was consisted of 151 patients with coronary heart disease(CHD),the healthy control group was consisted of 127 without CHD.Patients with CHD were compared with those persons in the healthy control group.AGT gene polymorphisms was tested with polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) technology and ACE gene polymorphisms was tested with PCR. Results The ratio of AGT-TT and ACE-DD genetype in CHD group was separately 76.26% and 35.10%,which was significantly higher than the control group(44.10% and 14.96%).There was significant difference of the AGT-TT genetype between the CHD group and the control group P><0.01;so was ACE-DD genetype between the two group(P><0.01). Conclusion In the population of Chinese miao nationality,the gene polymorphisms of genetype AGT-TT and genetype ACE-DD are two risk factors of CHD morbidity and they are both independent of each other but also mutually coordinated.