Aim To assess effect of different lipid levels on coronary lesion progression. Methods Patients were studied who successfully underwent PCI and were received coronary angiography again after three months to one year(average 7.4±2.2 months).95 patients had coronary lesion progression. 307 cases had no restenosis and lesion progression.Total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDLC) and low density lipoprotein-cholesterol(LDLC) were determined before perscutaneous coronary intervention(PCI) and re-angiography.Non high density lipoprotein-cholesterol(non-HDLC)=TC-HDLC. Results The levels of TC,LDLC and non-HDLC with follow-up angiography in lesion progression group were higher than those in control group(TC: 4.62±1.14 mmol/L vs 4.26±1.01 mmol/L,LDLC: 2.51±0.93 mmol/L vs 2.25±0.75 mmol/L,non-HDLC: 3.52±1.12 mmol/L vs 3.20±0.98 mmol/L,respectively,P><0.05).Logistic regression showed that the risk of lesion progression was markedly associated with concentrations of TC,LDLC and non-HDLC. Conclusion The levels of TC,LDLC and non-HDLC are the important risk factors for coronary lesion progression.Secondary prevention should be long-term emphasized and strengthened and non HDLC level should be controlled for patients with coronary artery disease.