The rapid development of glycobiology and glycosylation make an advancement in medicine. The high incidence of cardiovascular diseases,such as atherosclerosis,hypertension,and complication caused by diabetes mellitus,seriously influenced the quality of people's life. Glycosyltransferase plays an important role in it. In recent years,people develop many new clinical drugs in application of glycosyltransferase. The study of glycosyltransferase and glucoprotein is being a new front edge of life science,which will be of great benefit for human. This article discusses the advance of glycosyltransferase in atherosclerosis.