Aim To observe the effects of degradable coating and non-degradable coating with sirolimus-eluting stents on systemic and local levels of high sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6).Methods Consecutive 118 patients with unstable angina pectoris(UAP)with a stent implanted were involved and divided into non-degradable coating group(n=65)and degradable coating group(n=53).The serum concentrations of hs-CRP and IL-6 were determined before and immediately,at 48 hours,7 days,and 9 months after coronary intervention,and local levels in coronary were determined before and immediately,at 9 months after stent implantation.Results There was no significant difference in clinical and angiographic baseline characteristics and basic serum hs-CRP and IL-6 concentrations between the two groups.The local IL-6 levels increased immediately after stent implation in both group.The circulatory serum hs-CRP and IL-6 levels at 48 hours and 7 days after stenting were significantly higher in both group compared with baseline.When compared between the two groups,there was no significant difference of hs-CRP and IL-6 levels at 48 hours,7 days,and 9 months after stenting both in systemic and in local levels.Conclusion It seemed that degradable coating and non-degradable coating with sirolimus-eluting stents may display similar effects on systemic and local inflammation.