Aim To observe the protective effects of Edaravone injection and Captopril in patients of myocardial ischemia-reperfusion injury.Methods 68 eligible patients of CPB heart surgery in the year of 2009~2010 were selected and divided randomly and averagely into treatment group(n=34)and control group(n=34).The treatment group will be given Edaravone injection and Captopril.The control group will just be given Edaravone injection.Then the researcher will observe the incidence of arrhythmia,changes of heart rate and detect the contents of CK-MB,cTnI,artery angiotensionⅡ(AngⅡ)and MDA,SOD and NO by mining the radical artery after 120 minutes of the reperfusion.Results The content of CK-MB,cTnI,AngⅡand MDA in treatment group was lower obviously.However,there is obvious increase in content of SOD and NO.Compared with the control group,the differences were statistically significant for the research(P><0.05).Conclusion Edaravone injection and Captopril will reduce the incidence of arrhythmia and heart rate,increase the activities of myocardial SOD and NO.It can reduce the MDA production and the myocardial ischemia reperfusion injury and effectively protect the myocardial function.