After the injury of vascular endothelial,bone marrow-derived endothelial progenitor cell can be mobilized into the peripheral circulation,home to ischemic areas or sites of vascular damage,inducing endothelial cell proliferation,migration or differentiating into functional mature endothelial cell to promote the reendothelization of the damaged vessels.So it may become a new tool for treatment of cardiovascular disease.However,the signaling pathway that regulates endothelial progenitor cell proliferation,migration,differentiation and other biological characteristics needs to be thoroughly researched,which is not only difficult,but also hot in this area.This review will focus on the research regulation of endothelial progenitor cell signaling pathway.