AimTo investigate the relationship between non-alcoholic fatty liver (NAFL) and peripheral atherosclerosis.Methods300 physical examines had selected to enter the study.All participants were divided into NAFL group and non-NAFL group, NAFL group included 138 cases, non-NAFL group included 162 cases. Age and gender composition had no significant difference in the two groups (p＞0.05). Anthropometry indicators, brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index were measured. Fatty liver was measured via ultrasonography.ResultsWeight, body mass index (BMI), waistline, baPWV，systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) were significantly higher in the NAFL group than those in the non-NAFL group (p<0.05). The detection rates of obesity, hypertension and peripheral atherosclerosis in the NAFL group were significantly higher than those in the non-NAFL group (p<0.01).Logistic regression analysis showed that BMI, baPWV and ALT were susceptible factors of NAFL.ConclusionbaPWV is closely associated with NAFL. There is a close relationship between NAFL and peripheral atherosclerosis.