AimTo research on the influence of variety of cardiovascular disease on carotid artery intima-media thickness（IMT）and heart rate variability（HRV） in elderly hypertension patient.Methods192 senile hypertension were selected for A group,152 senile hypertension with coronary heart disease (CHD) as B group, 145 senile hypertension with diabetes(DM) as C group,184 senile hypertension with CHD and DM as D group.Clinical features, carotid atherosclerosis and Holter report (supervision) of four groups were analyzed.ResultsFasting blood-glucose (FBG), serum total cholesterol (TC), and IMT in patients of D group were significantly different from those in A,B,C group (p<0.05).The average heart rate and night heart rate were highest in D group.The incidence of ventricular premature beat, atrial arrhythmia, ischemic ST segment depression and HRV in the Holter reports of patients in D group was higher than A, B, C group(p<0.05).ConclusionFBG and TC are highest in senile hypertension with CHD and DM.The incidence of atherosclerotic plaque significantly increases in senile hypertension with CHD and DM.And also it tends to showing up depression HRV obviously.