Aim To study the risk factors of progressive ischemic stroke(PIS) and provide reference for the mechanism of PIS. Methods 356 cases of PIS patients were analyzed retrospectively and were divided into progress groups and non-progress group with four types according to OCSP.Compared the incidence of various subtype,the related factors of PIS were analyzed by logistic regression method,screening PIS risk factors. Results The incidence of TACI subtype was the highest than that of the other subtypes(P<0.05). The hypertension history and the incidence of carotid atherosclerosis in the progress groups were significantly higher than that of the non-progress group(P<0.05),the blood glucose,cholesterol,triglycerides and fibrinogen level in the progress groups were significantly higher than that of the non-progress group(P<0.05).Carotid atherosclerosis and high blood sugar were the risk factors of PIS. Conclusion The incidence of PIS in the OCSP subtypes was varied;the incidence of PIS was the highest in the TACI subtype;Carotid atherosclerosis and high blood sugar were the risk factors of PIS.