Aim To explore the effect of Shuxuetong injection combined with captopril on elderly hypertension patients' plasma endothelin(ET) and nitric oxide(NO) contents. Methods Elderly patients with hypertension were randomly divided into treatment group(n=40) and control group(n=36).Treatment group was treated with Shuxuetong injection and captopril,while control group was only given captopril,with 14d as a period course.The change of circadian rhythm of blood pressure,plasma ET and NO after treated for one course was observed. Results The treatment group was better than control group in antihypertensive effects(P<0.01).The improvement of rhythm diurnal variation by traditional and western medicine was better than control group in elderly hypertension.Compared with control group,treatment group's change of plasma ET and NO level had significant difference(P<0.05). Conclusions The combination of Shuxuetong injection and captopril can effectively improve elderly patients' circadian rhythm of blood pressure,increase the NO contents and decrease plasma ET.It has a better effect of longtime hypotensive,and it is worth in clinical widely.