Aim To investigate the levels of soluble low density lipoprotein receptor(sLR11),myeloid-related protein-8/14(MRP8/14) and eosinophil cationic protein(ECP) in coronary heart disease and their relationships with coronary artery disease. Methods The levels of serum sLR11,MRP8/14 and ECP were measured by enzyme-linked immunosorbent assay in 71 patients with acute coronary syndrome(ACS),51 patients with stable angina pectoris(SAP),and 53 controls.All subjects were underwent coronary angiography.The numbers of impaired coronary arteries,Gensini scoring of coronary stenosis and the levels of serum sLR11,MRP8/14 and ECP were compared respectively. Results The levels of sLR11,MRP8/14 and ECP in ACS group and SAP group were significantly higher than those in the controls(P<0.01),the levels of sLR11,MRP8/14 in ACS group were significantly higher than those in SAP group(30.50±10.48 ng/L vs 22.13±6.33 ng/L and 40.30±12.59 ng/L vs 29.12±10.27 ng/L,P<0.05).The ECP levels of ACS group were slightly higher than SAP group,but there were no significant difference(29.47±7.16 μg/L vs 23.73±5.67 μg/L,P>0.05).The serum levels of sLR11 and ECP were significantly higher in three impaired coronary arteries than two vessels and one vessel impaired group(P<0.01),but there were no significantly difference between 2-vessels and 1-vessel impaired group(P>0.05).There were obvious positive correlations in the levels of serum sLR11,ECP with Gensini score(P<0.01),however,there were no correlations in the levels of serum MRP8/14 with them(P>0.05). Conclusions There were correlations in the levels of serum sLR11,ECP levels with impaired coronary arteries and coronary stenosis,ECP played a key role in plaque growth,predicting atherosclerosis burden;MRP8/14 may suggest atherosclerosis plaque instability,predictability of acute coronary events.The serum levels of sLR11,MRP8/14 and ECP were significantly increased in coronary heart disease patients,improving the classification performance of cardiovascular risk factors,which were expected to become the new circulating biomarkers of coronary atherosclerosis.