Aim To explore the relationship between apolipoprotein CⅢ(ApoCⅢ) gene C3175G,T3206G polymorphism and the levels of serum lipids in male,as well as the multiple risk factors of overweight-obesity.Methods A total 337 males were selected from two hospitals by using DNA sequencing,and the apolipoprotein CⅢ gene C3175G,T3206G polymorphism and the serum lipids were determined and analyzed their relationships were analyzed.Results The genotype frequencies of the CC,CG and GG for ApoCⅢ3175 were 51.93%,40.06% and 8.01%,respectively,and C allele was 71.9% and G allele was 28.04%.The frequencies of TT,TG and GG for ApoCⅢ3206 were 6.82%,32.34% and 60.83%,respectively,and T was 23.0% and G was 77.0%.The carriers of ApoCⅢ3157G could have the higher level of triglyceride(TG).According to stratified selection of TG,there were relationships between ApoCⅢ and TC /LDLC.The mμltiple linear regression showed that abdomen obesity and ApoCⅢC3157G polymorphism might be associated with TG.Conclusion The ApoCⅢC3157G is related to the levels of serum TG and the results were supported the relationships between ApoCⅢT3206G and TC/LDLC in population with high TG.