Aim To observe high sensitivity C-reactive protein(hs-CRP),soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular cell adhesion molecule-1(sVCAM-1) and brachial artery endothelial function in different glucose tolerance level of patients with stable angina pectoris(SAP),and analyze the correlation of hs-CRP,sICAM-1,sVCAM-1 and brachial artery endothelial function.Methods Sixty SAP patients who confirmed by coronary angiography were selected.By OGTT,the sixty patients were divided into three groups: normal glucose tolerance(NGT)group,impaired glucose tolerance(IGT) group and type 2 diabetes(T2DM) group,20 patients in each group.Hs-CRP,sICAM and sVCAM levels were detected by enzyme linked immunosorbent assay.The flow-mediated dilation(FMD) in the brachial artery were detected by high-resolution ultrasound.Results The levels of hs-CRP in NGT group,IGT group and T2DM group were respectively 1.03±0.32 mg/L,2.14±0.82 mg/L and 3.05±1.56 mg/L,there was statistic difference between NGT group and T2DM group(P<0.05).The levels of sICAM-1 in NGT group,IGT gr-oup and T2DM group were respectively 112.76±32.03 μg/L,175.37±41.21 μg/L and 234.21±56.14 μg/L,the levels of sVCAM-1 in NGT group,IGT group and T2DM group were respectively 214.04±92.34 μg/L,314.56±101.69 μg/L and 485.89±173.24 μg/L,there was statistic difference between NGT group and T2DM group.The FMD in NGT group,IGT group and T2DM group were respectively 5.87%±2.52%,4.06%±2.02% and 2.03%±0.98%,there were statistic differentce between each groups(P<0.05).After correcting effection of gender,age,smoking,BMI,blood lipids and blood pressure,the closed relation was found between hs-CRP and endothelial function(P<0.05).Conclusions The endothelial function of SAP patients was decreased with the decrement of carbohydrate tolerance,while the hs-CRP level was increased.The hs-CRP level is significantly correlated with endothelial function.