Aim To assess the arteriosclerosis by pulse wave velocity(PWV) for providing a reference for the diagnosis of pseudohypertension.Methods Thirty inpatients(male 17,female 13) with coronary angiography whose ages were between 55~85 years,were divided into two groups,one group was the pseudohypertension,the other was the comparison.The brachial artery blood pressure and the indirect blood pressure were measured three times simultaneously after coronary angiography,and the difference between direct and indirect systolic and diastolic blood pressure was calculated.The bilateral ankle-brachial PWV(BaPWV) were measured using the atherosclerosis detector and the factors such as ages,diseases,body mass index,blood lipid levels and so on were observed.Results There were no significant difference in age,heart rate,the proportion of smoking,coronary disease,diabetes,and hyperlipidemia between the two groups.But the pulse pressure(P=0.001),non-invasive blood pressure(P=0.018) and the difference between non-invasive blood pressure and the direct blood pressure were opposite(P<0.05).If there were no difference in the PWV references between the two groups,the PWV measurements of the pseudohypertension were significantly distinct from the non-pseudohypertension(P=0.029).The BaPWV was the most sensitive(80.8%) and specific(73.3%) which was more than 1896.0 cm/s through the ROC curve for prediction of pseudohypertension.Pearson correlation coefficient was 0.431 between the two which had a medium relevance by the Pearson correlative analysis.Conclusion BaPWV anomalies can be valuable for diagnosis of pseudohypertension.