AimTo investigate the relationship between pathogenesis of atherosclerosis and nonalcoholic fatty liver disease(NFLD).Methods64 SD rats were randomly divided into two groups: normal control group with normal basic diet and high-sucrose and high-fat diet group with high sucrose and high fat diet.Each group was divided into four phases: 3 months, 6 months, 9 months and 12 months.Each phase had eight rats.Alanine aminotrnsferase,free fatty acid(FFA), triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL), fasting plasm glucose(FPG), fasting insulin(FIN), and endotoxin(LPS), tumor necrosis factor-α(TNF-α), C-reaction factor(CRP), macrophagocyte chemotaxis protein-1 (MCP-1), nitrc oxide(NO), endothelin-1(ET-1) were measured by ELISA; All the rats were killed and their livers and arterial specimens were taken to carry on HE stain for observing their