AimTo observe the effects of atorvastatin on NF-κB and its related inflammatory factors of ICAM-1, VCAM-1, MCP-1, IL-6, TNF-α in balloon injury model of common carotid artery in rats.MethodsIn the experiment, a total of 72 male healthy Wistar rats between 300 and 350 gram were randomly divided into three groups.They were as the followings: ① blank control group which were operated without balloon injury or atorvastatin; ②placebo control group which were operated and injured by balloon without atorvastatin; ③experimental group which were operated and injured by balloon with atorvastatin.In the experiment, the experimental group were given atorvastatin by 10mg/（kg·d) while the two control groups were given the same amount of water instead.After 3 days, all the rats were operated.However, blank control group were operated only without balloon injury.In each group, 6 of them were killed at 1, 3, 7, 14 days after operation and their blood samples and carotid arteryspecimens were taken respectively.Intimal hyperplasia was detected by histomorphology.NF-κB and its downstream factors were detected by immunohistochemistry.ResultsThe hyperplasia area of intima after balloon injury in the experiment group was significantly smaller than the placebo control group (P<0.01);The expression of NF-κB and its related factors in vascular wall and serum of the placebo control