血压正常高值者动态血压负荷及血压变异性与肿瘤坏死因子α的相关性
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山东省自然科学基金 (ZR2009CL029)资助;山东省医药卫生科技发展计划项目(2009HW080);山东省医学科学院资助项目[2009(16)、(17),2010(13)]


Relationship Between Blood Pressure Load, Blood Pressure Variability and Tumor Necrosis Factor-α in Prehypertensives
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    目的探讨血压正常高值者动态血压负荷及血压变异性与肿瘤坏死因子α(TNF-a)的关系。方法选择理想血压者100例,血压正常高值者105例,高血压患者110例,进行24 h动态血压监测,分别计算三组动态血压负荷及血压变异性,并测定TNF-a水平。结果血压正常高值组TNF-a水平、24 h、白昼及夜间动态血压负荷高于理想血压组,低于高血压组(p<0.01)。血压正常高值组24 h、白昼及夜间血压变异性高于理想血压组,24 h及白昼收缩压变异性、24 h及夜间舒张压变异性低于高血压组(p<0.05)。Pearson相关分析及多元逐步线性回归分析显示,血压正常高值组TNF-α与24 h收缩压负荷、24 h舒张压负荷、24 h收缩压变异性、白昼收缩压负荷、夜间舒张压负荷、夜间收缩压变异性呈正相关(p<0.05),24 h收缩压负荷及变异性、夜间收缩压负荷及变异性是TNF-α的影响因素(p<0.01)。结论血压正常高值者动态血压负荷及血压变异性与TNF-α相关,高血压早期炎症与血压升高有关。

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    AimTo investigate the relationship between blood pressure load, blood pressure variability and tumor necrosis factor-α (TNF-a) in prehypertensives.Methods100 normotensives and 105 prehypertensives were recruited, while 110 hypertensives were enrolled.24 h ambulatory blood pressure monitoring was carried out in the three groups, blood pressure load and variability was computed and TNF-a was measured respectively.ResultsTNF-a, blood pressure load during 24 h, daytime and nighttime in prehypertensives were higher than that in normotensives while lower than that in hypertensives (p<0.01).Blood pressure variability during 24 h, daytime and nighttime in prehypertensives were higher than that in normotensives (p<0.05).The systolic blood pressure variability during 24 h and daytime and the diastolic blood pressure variability during 24 h and night in prehypertensives were lower than that in hypertensives (p<0.05).Pearson correlation analysis and multiple linear stepwise regression showed that the level of TNF-α was positively correlated with the systolic blood pressure load during 24 h and daytime, the diastolic blood pressure load during 24 h and nighttime, the systolic blood pressure variability during 24 h and nighttime (p<0.05).The systolic blood pressure load during 24 h and nighttime as well as systolic blood pressure variability during 24 h and nighttime were risk factors for TNF-a (p<0.01).ConclusionsBlood pressure load and blood pressure variability was correlated with TNF-a.Inflammation was relevant to the level of blood pressure in prehypertensives.

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李俊,路方红,刘振东,赵颖馨,王舒健.血压正常高值者动态血压负荷及血压变异性与肿瘤坏死因子α的相关性[J].中国动脉硬化杂志,2012,20(6):541~544.

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  • 收稿日期:2011-06-22
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