AimTo observe the effect of atorvastatin on serum adiponectin and blood vessel endothelium function in patients with hyperlipemia combined with stable angina pectoris and asymptomatic coronary artery disease.Method150 cases with hyperlipemia combined with stable angina pectoris and asymptomatic coronary artery disease were randomly divided into three groups.Control group was given conventional treatment of coronary heart disease; observation group Ⅰ was treated with additional atorvastatin 20 mg/d; observation group Ⅱ received additional atorvastatin 40 mg/d.The treatment duration was 12 weeks.Fasting venous blood was collected to detect serum levels of adiponectin, serum amyloid A，nitric oxide and endothelin-1.The changes of nitric oxide and endothelin-1 were used as indirect indexes for blood vessel endothelium function.ResultsAfter treatment, serum levels of adiponectin and nitric oxide were increased, but endothelin-1 and serum amyloid A were decreased in observation group Ⅰ and Ⅱ(all p<0.05)， with significantly greater changes of each index in observation group Ⅱ than those in group Ⅰ.Serum adiponectin correlated significantly with nitric oxide, and was inversely related to endothelin-1 and serum amyloid A.ConclusionAtorvastatin improves blood vessel endothelium function via reduction of serum adiponectin level.This agent may play an important role in the prevention of atherosclerosis.