AimTo evaluate the differences of the changes of arterial stiffness of hypertension patients with the treatment of calcium channel blocker (CCB) or angiotensin Ⅱ receptor blocker (ARB).MethodsBased on the principles of evidence-based medicine, corresponding inclusion and exclusion criteria, along with search strategies were developed.We searched the Ovid EMB Reviews, Pubmed, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journal Full-text Database, and Chinese Journal Full-text Database up to January 2012 to identify randomized controlled trials (RCT) comparing the effects of CCB with that of ARB on arterial stiffness of hypertension patients.Two reviewers independently evaluated the quality of the included studies, extracted data with a unified form, and analyzed the data by Cochrane Collaboration’s RevMan 5.0 software.We compared the effects of CCB with ARB on pulse wave velocity (PWV), SBP, DBP and PP of hypertension patients.ResultsSix RCT involving 411 paitents were included.The results of Meta analysis suggested that ARB was better than CCB in reducing arterial stiffness (MD＝183.33, 95％CI was 79.32～ 287.33), but worse than CCB in lowering SBP (MD＝－2.66, 95％CI was －3.35 ～－1.96) or DBP (MD＝－5.43, 95％CI was －8.8～－2.07).ConclusionIn the treatment of anti-hypertension, CCB is stronger than ARB.But the effect of ARB is better than that of CCB on reducing arterial stiffness.And it’s not related to their antihypertensive function.However, due to the quality of the included studies, the effects of CCB and ARB on arterial stiffness need to be confirmed by large multicenter randomized controlled trials.