Hydrogen sulfide is a toxic gas with rotten eggs taste. However,there were a large number of articles reported that hydrogen sulfide was the third gaseous signaling molecule after CO and NO in recent years. Hydrogen sulfide derived mainly from cystathionine b-synthase,cystathionine c-lyase and 3-Mercaptopyruvate sulfurtransferase enzyme,which had many roles such as blood vessel dilatation,regulating blood pressure,inhibiting vascular smooth muscle cell proliferation and low density lipoprotein （LDL） oxidative modification. Especially hydrogen sulfide has a significant protective role on ischemic myocardial cells. Studies have shown that the potassium channels may be involved in various forms and multiple organ ischemia protection. Hydrogen sulfide is an important gaseous signaling molecule,of which improving blood perfusion levels may be related to the potassium channel. This review focuses on the role of potassium channel during the process of hydrogen sulfide producing biological effect.