Aim To observe the expression of integrin β₃ by making rat model of abdominal aortic aneurysm and explore the significance of integrin β₃ in the pathogenesis of abdominal aortic aneurysm. Methods Making a rat model of abdominal aortic aneurysm and measuring the diameter of all aortas then calculating their extended rate of the aorta. HE staining was used to observe the change of pathology. Immunohistochemistry and real time PCR were used to detect the expression of integrin β₃ from the level of protein and gene. Results Rat model of abdominal aortic aneurysm was successfully made. Compared with saline group and normal group(1.175±0.159 and 1), the extended rate of experimental group (3.689±0.443) was obviously rising and the infiltration of inflammatory cell was more apparent (P<0.05). Immunohistochemistry showed that the expression of integrin β₃ in experimental group, saline group and normal group were 0.33±0.07,0.20±0.06 and 0.19±0.07 (P<0.05);Real time PCR showed the expression of integrin β₃ mRNA in experimental group, saline group and normal group were 36.23±5.65, 1.14±0.30 and 1 (P<0.05). Conclusions The increasing expression of integrin β₃ may participate in the occurrence and development of experimental abdominal aneurysms.