Aim To explore the associations of angiotensin Ⅱ type 1 receptor (AT1R) A1166C variant with blood pressure in Chinese. Methods We invited all unrelated employees and retired workers to take part in this study, and 1466 participants were included in the present analysis. Standardized questionnaires were used to collect information on alcohol consumption, smoking habits, and use of medications. The AT1R genotype was determined by SNaPshot method. Results One thousand four hundred and sixty six participants included 566 (37.9%) women, 485 (33.1%) overweight/obese participants, 468 (31.9%) hypertensive patients, of whom 212 (45.3%) took antihypertensive treatment. The frequencies of AA, CA and CC were 90.5%, 9.4% and 0.1%, respectively. There was no significant difference in the distributions of genotypes and alleles between participants with normal blood pressure and hypertensive patients (P>0.05). Furthermore, there was no significant difference in systolic and diastolic blood pressure and pulse pressure between genotypes before and after adjusted for covariates (P>0.05). We found significant interaction between the A1166C variant and body mass index on systolic blood pressure (P_int＝0.002) and pulse pressure (P_int＝0.02). Only among participants in the highest quartile of body mass index (＞25.8 kg/m²), C allele carriers had significantly higher systolic blood pressure (P＝0.02) and pulse pressure (P＝0.009) than AA homozygotes. Conclusions Significant interactions were observed between AT1R A1166C variant and body mass index on systolic blood pressure and pulse pressure.