Aim To investigate the incidence and risk factor of coronary heart disease complicated with non-alcoholic fatty liver disease (NAFLD) in patients undergoing coronary angiogram. Methods 1346 patients with coronary heart disease who underwent coronary angiogram were enrolled into this study. All patients had ultrasound screening for fatty liver. Results Among 612 recruited patients, 678 (50.4%5) had fatty liver by ultrasonography. Incidence of NAFLD in the patients in 3-vessel disease was higher than those of 1, 2-vessel disease (P<0.01). By multivariable Logistic regression analysis, diabetes mellitus, multi-vessel lesions or stenosis of left main stem were risk factors in NAFLD patients with coronary heart disease. Conclusion In coronary heart disease patients, increase in the incidence of NAFLD were related to coronary atherosclerosis severity aggravating, especially the patients with diabetes mellitus.