Aim To study the relationship between coronary heart disease and pregnancy-associated plasma protein A (PAPP-A) for guiding the clinical work. Methods The articles relating to the analysis of coronary heart disease and pregnancy-associated plasma protein A (PAPP-A) were studied from the China Journal Full-text Database and Pubmed professional foreign language database collected from 2001 to 2012. The right articles were chosen and analyzed with RevMan 5.0 software.Results This article encompasses 10 studies, including 1091 objects of study. The results show that: The relationship between the stable angina and PAPP-A levels is 95% CI 0.02, 0.34 (P＝0.03) The relationship between unstable angina and PAPP-A levels is 95% CI 1.32, 1.74 (P<0.01) The relationship between acute myocardial infarction and PAPP-A levels is 95% CI 1.83, 2.38 (P<0.01). And the relationship between one coronary artery disease and PAPP-A levels is 95% CI 1.78, 2.50 (P<0.01) for two coronary arteries disease, it is 95% CI 1.83, 7.72 (P<0.01) for three coronary arteries disease, it is 95% CI 2.39, 3.26 (P<0.01). According to all these results of the study, it shows that the mutation quantity of coronary heart disease and coronary artery is highly connected with pregnancy associated plasma protein-A. And its of significance to statistics study. Conclusion Through the study, it shows that the quantity of coronary heart disease and coronary artery lesion has close relationships with pregnancy-associated plasma protein A.