Aim To investigate the effects of angiotensin （1-7） ［Ang（1-7）］ on the expression of lipids and reverse cholesterol transport related factors: ATP binding cassette transporter A1 （ABCA1）, peroxisome proliferator-activated receptor γ （PPARγ）, liver X receptor α （LXRα） and retinoid X receptor α （RXRα） in rats. Methods 40 healthy SD male rats were randomly divided into normal control group, high-fat diet group, Ang（1-7） group and Ang（1-7）＋A779 group. Ang（1-7） was continuably given by osmotic pump and jugular vein cannulation, after 28 d, total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDLC） and high density lipoprotein cholesterol （HDLC） in rat plasma were detected, gene expression of ABCA1, PPARγ, LXRα and RXRα in the aortic tissues of rats were measured by quantitative real-time polymerase chain reaction （qRT-PCR） and Western blot. Results Compared with the normal control group, TC, TG, LDLC of high-fat diet group were increased （P<0.05）, HDLC of high-fat diet group were lower （P<0.05） compared with high-fat diet group, TC, TG, LDLC of Ang（1-7） group were lower （P<0.05）, HDLC of Ang（1-7） group were increased （P<0.05） compared with Ang（1-7） group, TC, TG, LDLC of Ang（1-7）＋A779 group were increased （P<0.05）, HDLC of Ang（1-7）＋A779 group were lower （P<0.05）. Compared with the normal control group, ABCA1, PPARγ, LXRα, RXRα mRNA and protein levels of high-fat diet group were lower （P<0.05） compared with high-fat diet group, ABCA1, PPARγ, LXRα, RXRα mRNA and protein levels of Ang（1-7） group were increased （P<0.05） compared with Ang（1-7） group, ABCA1, PPARγ, LXRα, RXRα mRNA and protein levels of Ang（1-7）＋A779 group were lower （P<0.05）. Conclusion Ang（1-7） reduced the lipid levels in rat plasma, raised the gene expression of ABCA1, PPARγ, LXRα and RXRα in the aortic tissues of rats, cured the hyperlipidemia.