不同类型肥胖对原发性高血压患者动脉僵硬度的影响
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山东省自然科学基金项目(ZR2011HQ053,ZR2009CL029)


Effect of Different Obese Type on Arterial Stiffness in Essential Hypertension
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    摘要:

    目的 探讨不同类型肥胖对原发性高血压患者动脉僵硬度的影响。方法 选择原发性高血压患者776例,根据体质指数(BMI)和腰围将受试者分为4组:正常BMI+正常腰围组(正常组,n194)、正常BMI+腰围增高组(单纯腰围增高组,n195)、BMI增高+正常腰围组(单纯BMI增高组,n196)及BMI增高+腰围增高组(BMI和腰围增高组,n191)。测定所有受试者肱踝脉搏波传导速度和踝臂指数;根据受试者的血脂情况,计算动脉硬化指数。结果 BMI和腰围增高组受试者的肱踝脉搏波传导速度(2120±263 mm/s)和动脉硬化指数(3.35±0.87)明显高于正常组(P<0.01)及单纯腰围增高组和单纯BMI增高组(P<0.05)。BMI和腰围增高组受试者的踝臂指数(0.72±0.15)明显低于正常组(P<0.01)及单纯腰围增高组和单纯BMI增高组(P<0.05)。单纯BMI增高组受试者的踝臂指数及动脉硬化指数与单纯腰围增高组无统计学差异(P>0.05)。析因分析结果显示,BMI和腰围增高对动脉僵硬度的影响均显著,且二者存在协同效应。结论 腹型肥胖的原发性高血压患者动脉弹性受损程度严重,BMI和腰围增高对动脉弹性功能受损有交互协同作用。

    Abstract:

    Aim To investigate the effect of different obese type on arterial stiffness in essential hypertension. Methods The basic information was collected in a total of 776 essential hypertensive patients. According to body mass index (BMI) and waist circumference (WC) level, all patients were divided into four groups, namely, normal BMI and normal waist circumference group (Ⅰgroup, n194), normal BMI and elevated waist circumference group (Ⅱgroup, n195), excessive BMI and normal waist circumference group (Ⅲ group, n196), excessive BMI and elevated waist circumference group (Ⅳgroup, n191). Brachial ankle pulse wave velocity (BaPWV) and ankle-brachial blood pressure index (ABI) were observed in all patients. Arterial stiffness index (AI) was calculated using the blood lipid of all hypertension patients. Results BaPWV (2120±263 mm/s) and AI (3.35±0.87) in Ⅳ group were significantly higher than Ⅰgroup (P<0.01), Ⅱgroup and Ⅲ group (P<0.05). ABI (0.72±0.15) in Ⅳ group were significantly lower than Ⅰgroup (P<0.01), Ⅱgroup and Ⅲ group (P<0.05). There were no statistical differences between Ⅱgroup and Ⅲ group in ABI and AI (P>0.05). Results of 2×2 factorial analysis showed that there was a distinctive and synergistic effect between excessive BMI and elevated waist circumference on arterial stiffness. Conclusion Arterial elasticity function was aggravatedly damaged in essential hypertension in patients with abdominal obesity. Excessive BMI and elevated waist circumference had interaction and synergistic effect on the damage of arterial elasticity function.

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宋洪斌,刘振东,路方红,刁玉涛,张 华,赵颖馨,孙尚文,齐在文.不同类型肥胖对原发性高血压患者动脉僵硬度的影响[J].中国动脉硬化杂志,2013,21(08):737~740.

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  • 收稿日期:2013-01-16
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