维持性血液透析患者骨代谢指标变化及相关分析
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Clinical Analysis of Index of Bone Metabolism Changes in Maintained Hemodialysis Patients
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    目的 调查维持性血液透析患者中钙、磷及血清全段甲状旁腺激素(iPTH)水平的差异。方法 以98例透析龄>3月的血液透析患者作为调查对象,根据患者透析龄的长短将患者分为透析龄<12月组、12月<透析龄<36月组以及透析龄≥36月组;生物化学仪分析各组间血钙、血磷、血肌酐、尿素氮等,采用ELISA法检测患者透析前iPTH水平。结果 血液透析患者随透析龄延长iPTH 水平逐步升高 (P<0.05);在短透析龄(透析龄<36月)患者中糖尿病患者iPTH水平低于非糖尿病者,差异具有显著性 (P<0.05);回归分析显示,iPTH与血磷和透析龄相关。结论 长期血液透析患者iPTH水平随透析龄延长而升高且与高血磷相关。

    Abstract:

    Aim To investigate the levels of calcium and phosphorus disturbance and intact parathyroid hormone (iPTH) in maintained hemodialysis(HD) patients. Methods The study included 98 patients,who were on haemodialysis treatment for 3~192 months. Patients in a group were subdivided into dialysis age <12 months group and 12 months<dialysis age <36 months group and dialysis age ≥36 months group. iPTH level and clinical data were compared among the groups. Results Serum iPTH was significantly higher in dialysis age ≥36 months group than that in dialysis age <12 months group and 12 months<dialysis age <36 months group(P<0.05). iPTH level was significantly lower in diabetic patients with short dialysis age(dialysis age <36 months) than that in nondiabetic patients (P<0.05).

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陈高翔,王友云,李 蕾,肖锦华.维持性血液透析患者骨代谢指标变化及相关分析[J].中国动脉硬化杂志,2013,21(10):927~930.

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  • 收稿日期:2012-09-11
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