心率和心率变异性与心力衰竭及预后的相关性
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Heart Rate and Heart Rate Variability Relation to Heart Failure and Prognosis
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    摘要:

    目的 探讨心率及心率变异性与心力衰竭及预后的相关性。方法 入选2010年10月至2012年6月期间就诊宁夏医科大学总医院心内科的慢性充血性心力衰竭患者245例,根据住院期间平均静息心率水平分为3组:A组:50~70次/分;B组:71~90次/分;C组:>90次/分;共随访1年,完成随访共230例。其中共有97例行动态心电图检查,按患者心功能分级分为Ⅱ级组、Ⅲ级组、Ⅳ级组,同时选择26例正常健康人为对照组。收集上述研究对象的心率变异性时域指标进行对比分析,包括正常RR间期标准差(SDNN)、5 min均值标准差(SDANN)、相邻RR间期相差>50 ms的个数占总心跳数的百分比(PNN50)、全程相邻RR间期之差的平方根(RMSSD)。结果随着心率水平增加,随访终点射血分数明显降低,再住院率及病死率明显增加(P<0.01)。不同心率水平心力衰竭患者Cox生存分析显示心率越快,生存率越低。心力衰竭组与对照组相比SDNN、SDANN、PNN50、RMSSD降低(P<0.01或P<0.05),随着心力衰竭程度的加重,SDNN、SDANN、PNN50、RMSSD下降越明显(P<0.01)。结论 心率越快,心力衰竭预后越差;心力衰竭患者存在心率变异性降低,心率变异性越低,心功能越差。

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    Aim To explore whether the heart rate and heart rate variability relation to heart failure and prognosis. Methods The 245 chronic heart failure patients admitted in General Hospital of Ningxia Medical University between October 2010 and June 2012 were enrolled in this study. Mean heart rate at rest was categorized into predefined groups: A group (50~70 beats/min), B group (71~90 beats/min), and C group (>90 beats/min). After one year follow-up, the clinical data of 230 patients was collected. 97 patients among them performed a holter monitoring. Based on functional classifications, they were divided into class Ⅰ, Ⅱ, Ⅲ, Ⅳ group and 26 healthy one as comparison. Heart rate variability indexs including standard deviation of all normal RR interval (SDNN), standard deviation of the 5 minute average RR interval (SDANN), the percentage of intervals>50 ms different from preceding interval (PNN50), square root of the mean of the squares of successive RR interval differences (RMSSD) were collected. Results With increased heart rate, ejection fraction decreased significantly and readmission and mortality rised up at the end of follow-up.

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张 辉,冯 婧,梁 婷,薛 莉.心率和心率变异性与心力衰竭及预后的相关性[J].中国动脉硬化杂志,2014,22(03):274~278.

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  • 收稿日期:2013-11-11
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