老年高血压患者动脉硬化与骨质疏松的相关性
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The Correlation Between Osteoporosis and Arterial Stiffness in Elderly Hypertensive Patients
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    目的 探讨老年高血压伴动脉硬化与骨质疏松的相关性。方法 收集我院年龄≥60岁住院患者149例,平均年龄72.7±10.1岁,其中109例原发性高血压患者为高血压组,40例非高血压患者为对照组,完善骨密度、四肢多普勒超声及相关生化检验等,将高血压组患者按照肱-踝脉搏波传导速度(BaPWV)以1900 cm/s为界分为高低两组,进行统计分析。结果 高血压组患者股骨颈、大转子、髋关节全部骨密度较对照组明显降低,差异有统计学意义(P<0.05)。左侧BaPWV≥1900 cm/s组患者股骨颈、大转子、粗隆间及髋关节全部骨密度较BaPWV<1900 cm/s组下降明显,差异有统计学意义(P<0.05 )。偏相关性分析示:控制年龄因素后左侧BaPWV与左侧髋关节大转子及髋关节全部骨密度仍呈负相关(r-0.191和-0.199,P<0.05)。Logistic回归分析示年龄、载脂蛋白B是动脉硬化的危险因素。结论 老年高血压患者骨质疏松的危险增加,且其动脉硬化与髋部骨密度存在相关性,同侧动脉硬化程度增加的患者髋部骨密度下降的风险增加。

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    Aim To investigate the relationship between osteoporosis and atherosclerosis in elderly hypertensive patients. Methods 149 patients (≥60 yesrs old,average age 72.7±10.1 yesrs old)were included, whose bone mineral density and brachial-ankle pulse wave velocity(BaPWV) were measured by dual energy X ray bone density and Doppler ultrasonography. Among them,109 patients with hypertension were used as the case group and 40 patients without hypertension were used as the control group. Results The neck bone mineral density, greater trochanter bone mineral density and the total hip bone mineral density were significantly lower in patients with hypertension group than the control group, and the difference was statistically significant(P<0.05). The neck bone mineral density, greater trochanter bone mineral density, intro bone mineral density, total hip bone mineral density were significantly lower in patients with high BaPWVL group than the low BaPWVL group, and the difference was statistically significant(P<0.05). After controlling the age, the bone mineral density was negatively correlated with the left BaPWV(r-0.191 and -0.199,P<0.05),and the difference was statistically significant. Logistic regression analysis show that age and apolipoprotein B were risk factors for atherosclerosis. Conclusion Hypertension is a risk factor for osteoporosis. Increased arterial stiffness is associated with reduced bone mineral density in hypertensive patients. Therefore, hypertensive patients with increased arterial stiffness may have a high risk of bone fracture due to osteoporosis.

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宋美香,周晓辉.老年高血压患者动脉硬化与骨质疏松的相关性[J].中国动脉硬化杂志,2014,22(04):371~376.

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  • 收稿日期:2013-06-24
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