As the third endogenous gasotransmitter,hydrogen sulfide（H₂S） has swept the research field. The overwhelming majority of researches have been involved in the field of H₂S with cardiovascular homoeostasis. However,the data referred to the functions of H₂S on mammal biological lipid metabolism are still lacking. In this article,we will give a brief introduction about the role of H₂S in biological lipid metabolism and some lipid metabolism related diseases. At the end of this article,some discussions about therapies based on H₂S are presented.