Aim To investigate the effect of ox-LDL on platelet extracellular matrix metalloproteinase inducer（EMMPRIN，CD147） release. Methods Washed platelets were incubated with ox-LDL （final concentrations of 25 mg/L, 50 mg/L or 100 mg/L ox-LDL, respectively）, PBS （as control） or 100 mg/L native LDL in vitro, and the expressions of CD147 and alpha-granule membrane glycoprotein （CD62P） on platelets were detected by flow cytometry. Soluble CD147 from the platelets was assessed by an enzyme-linked immunosorbent assay. Laser scanning microscopy （LSM） and transmission electron microscopy （TEM） were used to visualize the morphological changes and granule release, respectively, from the platelets. In parallel, the expression of CD147 on the platelets pre-incubated with anti-LOX-1 antibody was detected by flow cytometry. Results The CD147 relative mean fluorescence intensity （rMFI） from the groups of 25 mg/L, 50 mg/L or 100 mg/L ox-LDL （1.01±0.06，1.18±0.07, 1.24±0.08, respectively） were higher than that from the control group （0.86±0.10, both P<0.01） or native LDL group （0.89±0.11, both P<0.01）. The CD147 rMFI（0.96±0.08，1.05±0.07） from the platelets incubated with ox-LDL （50 mg/L or 100 mg/L） prior to pre-incubation with anti-LOX-1 antibody decreased compared with the 50 mg/L or 100 mg/L ox-LDL-treated platelets, respectively （both P<0.001）. After exposure to ox-LDL, morphological changes and granule release in the platelets were visualized by LSM and TEM. Conclusion ox-LDL induces the release of platelet CD147 via binding to LOX-1.