伴有高血压的2型糖尿病肾病患者尿白蛋白和肾脏血流变化及其关系研究
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云南省卫生科技成果三等奖(2011NK-3-3-007-02)


The Relationship Between Urine Albumin and Renal Blood Flow Changes in the Type 2 Diabetic Nephropathy Patients with Hypertension
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    目的 探讨伴有高血压的2型糖尿病肾病患者尿白蛋白和肾动脉血流指标变化及其关系。方法 75例伴有高血压的2型糖尿病肾病患者,根据尿白蛋白排泄率(UAER)分为3组:微量蛋白尿组、临床蛋白尿组、大量蛋白尿组;30例健康体检者为正常对照组。应用彩色多普勒血流显像(CDFI)及彩色多普勒能量显像(CDEI)检测双侧肾主动脉及叶间动脉的血流频谱,对各组测定指标进行比较分析;分析肾血流变化与UAER变化之间的关系。结果 伴有高血压的2型糖尿病肾病患者左肾、右肾的搏动指数和阻力指数与正常对照组比较差异均有统计学意义(P<0.05);且左肾、右肾的搏动指数和阻力指数随尿白蛋白排泄的增加而增高(P<0.05)。双肾主动脉、叶间动脉的收缩期最大流速、舒张期最小流速、阻力指数、加速度、加速时间,临床蛋白尿组、大量蛋白尿组与正常对照组比较,差异有统计学意义。Pearson相关分析表明,肾主动脉、叶间动脉的收缩期最大流速、舒张期最小流速、阻力指数均与UAER呈显著相关。结论 CDFI及CDEI检测肾动脉血流指标能为临床糖尿病肾病的早期诊断和评价预后提供重要依据。

    Abstract:

    Aim To explore the changes of urine albumin and renal blood flow parameters and their relationship in the type 2 diabetic nephropathy patients with hypertension. Methods 75 cases of type 2 diabetic nephropathy patients with hypertension,according to urinary albumin excretion rate (UAER),were divided into 3 groups: microalbuminuria group,clinical proteinuria group and mass albuminuria group.30 healthy persons were as normal control group.Bloodstream spectrums of bilateral master renal arteries (MRA) and interlobar renal arteries (IRA) were detected by using color Doppler flow imaging (CDFI) and color Doppler energy imaging (CDEI).The detective indexes of various groups were compared,and the relationships between renal blood flow and UAER changes were analyzed. Results The pulsatile index and resistance index (RI) differences of both kidney in type 2 diabetic nephropathy patients with hypertension had statistical significance compared to normal control group (P<0.05).The pulsatile index and RI were increased with urine albumin excretion enhancing (P<0.05).Systolic Vmax,diastolic Vmin,RI,HAAC,and SAT of MRA and IRA in clinical proteinuria group,mass albuminuria group were markedly different from those in normal control group.Pearson correlation analysis showed that the Vmax,Vmin and RI of MRA and IRA had significant correlation with UAER. Conclusion Renal arteries blood flow indexes detected by CDFI and CDEI can provide an important basis for the early diagnosis and evaluation of prognosis of clinical diabetic nephropathy.

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张 曦,李茹艳,于 璐,王 媛.伴有高血压的2型糖尿病肾病患者尿白蛋白和肾脏血流变化及其关系研究[J].中国动脉硬化杂志,2014,22(10):1030~1034.

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  • 收稿日期:2012-12-11
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