Aim Summary and analysis of the value of anterograde-retrograde and selective bypass graft vessel perfusion technology in severe coronary artery bypass grafting(CABG）. Methods Retrospective analysis was carried out for 152 cases of severe coronary artery disease in patients undergoing coronary artery bypass grafting. All operations were carried out under cardiopulmonary bypass(CPB）. During operation, anterograde-retrograde and selective bypass graft vessel perfusion method were taken for myocardial protection. Results All patients stayed stable during CPB. After operation, 5 patients had low cardiac output syndrome, 1 patients had renal insufficiency, 2 patients had hypoxemia, and they all recoverd after therapy, no patient died. Conclusion During CABG for severe coronary artery disease, anterograde-retrograde and selective bypass graft vessel perfusion technology have a good myocardial protection effect, and can significantly improve the prognosis of patients.