Aim To analyze the risk factors for triple-vessel coronary artery disease between different genders. Methods A total of 1 262 patients （907 males and 355 females）, who underwent coronary angiography and were diagnosed coronary heart disease, and their gender ,ages, hypertension, total cholesterol（TC）, triglycerides（TG）, low-density lipoprotein cholesterol （LDLC）, high-density lipoprotein cholesterol （HDLC）, uric acid（UA）, diabetes and smoking history were recorded. First, all cases were divided into two groups according to whether triple-vessel disease or not. Risk factors were compared between the two groups. Then they were further divided into groups based on gender, the risk factors between triple-vessel coronary artery disease and non-triple-vessel coronary artery disease in males and females were compared respectively. Results Univariate analysis showed that the age, male ratio, TC, LDLC, UA, hypertension ratio, diabetes ratio, smoking ratio of triple-vessel coronary artery disease were higher than non-triple-vessel coronary artery disease. The HDLC of triple-vessel coronary artery disease was lower than non-triple-vessel coronary artery disease. And the difference was statistically significant（P<0.05）. For males, the age, TC, LDLC, UA, diabetes ratio of triple-vessel coronary artery disease were higher than non-triple-vessel coronary artery disease. The HDLC of triple-vessel coronary artery disease was lower than non-triple-vessel coronary artery disease. And the difference was statistically significant（P<0.05）. For female, the age, LDLC, hypertension ratio, diabetes ratio of triple-vessel coronary artery disease were higher than non-triple-vessel coronary artery disease. The HDL-C of triple-vessel coronary artery disease was lower than non-triple-vessel coronary artery disease. And the difference was statistically significant（P<0.05）. Logistic regression analysis showed that the most significant risk factor for triple-vessel coronary artery disease were diabetes. Conclusion