Aim To study the effects of Xin Tong-tai (XTT) on levels of serum lipid and apolipoprotein A,Bü and aortic oxidized low density lipoprotein (ox-LDL) and interleukin-1β (IL-1β) in rabbits with hyperlipidemia. Methods 120 clean grade healthy Japanese rabbits were randomly divided into control group, model group, low-dose XTT group, middle-dose XTT group, high-dose XTT group and rosuvastatin group. All rabbits were sacrificed by high-fat diet and immunologic injury. The drug intervention groups were treated with the corresponding drugs for 60 days, serum lipid and apolipoprotein A,Bü were tested for determination. Ox-LDL and IL-1β were tested by immunohistochemistry. Results Compared with model group, XTT and rosuvastatin groups could decrease total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and apolipoprotein B, the difference was statistically significant (P<0.01 or P<0.05). Compared with model group, XTT and rosuvastatin groups could increase high density lipoprotein and apolipoprotein A, the difference was statistically significant (P<0.01 or P<0.05). Compared with model group, the decrease of IL-1β and ox-LDL in the middle-dose XTT, high-dose XTT and rosuvastatin groups had statistically significant difference (P<0.01). Conclusion The XTT can reduce inflammatory response of atherosclerosis, probably through lowering serum lipid and reducing inflammation.