Statins,3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, inhibit the rate-limiting enzyme in cholesterol synthesis and lead to a significant reduction of plasma lipid concentrations. As a clear correlation exists between serum cholesterol and cardiovascular risk, statins have become increasingly important in current preventive medicine. It is now widely accepted that cardiovascular disease prevention by statins is dependent not only on their lipid lowering effects, but also on their beneficial effects on anticoagulation etc. Anticoagulant effects of statins included prevention of venous thromboembolism, influence on the expression of coagulation factors, impact on physiological anticoagulants, suppression of inflammation and improvement in endothelial function. In this review, we provide an update on the current understanding of the interactions between statins and blood coagulation.