Aim To evaluate the lipid profile in non-treated patients with coronary artery disease (CAD); To explore the prediction factors of CAD. Methods 1772 patients with clinically suspected CAD and without use of lipid-regulating drugs were enrolled, and undergone by coronary angiography. 1057 cases were diagnosed as CAD, and 715 cases were without CAD. Blood lipid profiles of the two groups were analyzed and compared. Correlation between blood lipid levels and CAD was analyzed. Results The blood lipid profiles in patients with CAD were as follows:triglyceride 1.78 mmol/L (1.29-2.43 mmol/L), total cholesterol (TC) 4.92±0.99 mmol/L, high density lipoprotein cholesterol (HDLC) 1.09±0.29 mmol/L, low density lipoprotein cholesterol (LDLC) 3.22±0.91 mmol/L. LDLC and non-HDLC were able to meet the standards (LDLC＜1.81 mmol/L and non-HDLC＜2.59 mmol/L) in only 2.46% patients with CAD. In 50-59 years, 60-69 years, ≥70 years subgroups, the levels of TC, HDLC, apolipoprotein A1 (ApoA1) and ApoB in male patients were significantly lower than that in female patients (all P＜0.05). ApoB/ApoA1 was the strongest predictor of CAD. Conclusion Blood lipids levels are increased in CAD patients without use of lipid-regulating drugs, most of which are mild or moderate dyslipidemia, and standard-reaching rate of blood lipids is low. The degree of abnormal blood lipids is more serious in women. Correlation between non-HDLC, ApoB, LDLC/HDLC, ApoB/ApoA1 and CAD is good, which can predict the risk of CAD.