Atherosclerosis is a fairly common disease associated with heart and brain blood vessels, posing serious cardiovascular complications. Western medicine is the main means of treatment of atherosclerosis. In recent years, with the experimental and clinical research on atherosclerosis, the traditional Chinese medicine has made remarkable progress in the treatment of arteriosclerosis, but the therapeutic effect of atherosclerosis is still not satisfied. In this review, we will explore the relationship between the pathogenesis of traditional Chinese medicine and western medicine in atherosclerosis, and try to provide reference for atherosclerosis therapy with integrated Chinese and Western medicine.