Aim To investigate the relationship between serum uric acid (SUA) and mean platelet volume (MPV) in patients with coronary heart disease (CHD), and to analyze their predictive value for long-term cardiovascular events. Methods A total of 488 patients with CHD diagnosed by selective coronary angiography were included. SUA and MPV were detected and recorded in patients when admitted to hospital. The occurrence of first cardiovascular event in patients was collected and recorded during 5 years of follow-up. Results The median SUA and MPV in patients with CHD were 298.00 μmol/L and 11.05 fL, respectively. Correlation analysis showed that SUA was significantly positively correlated with MPV, fasting blood glucose, low density lipoprotein cholesterol, white blood cell count (r＝0.528, P＜0.001; r＝0.321, P＝0.015; r＝0.412, P＝0.027; r＝0.215, P＜0.001). Multiple stepwise regression analysis was performed to analyze the effect factors of MPV in patients with CHD, and the result showed that SUA and MPV remained independently associated (r＝0.265,P＝0.0137). Cardiovascular events occurred in 169 cases during 5 years of follow-up. COX multivariate regression analysis showed that SUA and MPV were independent predictors of long-term cardiovascular events in patients with CHD (SUA:HR 1.9,5%CI 1.12-2.25, P＝0.033; MPV:HR 1.9,5%CI 1.15-1.23, P＝0.013). Conclusion SUA and MPV are independently positively correlated; both SUA and MPV can accurately predict the future risk of cardiovascular events in patients with CHD.