Aim To study the clinical effect of coronary artery shunt in off-pump coronary artery bypass. Methods 86 cases of off-pump coronary artery bypass grafting were divided into two groups:application of coronary artery shunt group (experimental group, 43 cases) and no application of coronary artery shunt group (control group, 43 cases), creatine kinase-MB isoenzyme (CK-MB), cardiac troponin I (cTnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were monitored for 1~3 days after operation, and complication rate, ventilation time, ICU stay time and hospitalization time after operation were recorded . Results All cases were cured. The per capita number of coronary artery bypass grafting was 3~5 in the two groups, the number of coronary artery bypass grafts in the experimental group was 3.6±0.7, the number of coronary artery bypass grafts in the control group was 3.6±0.6, there was no significant difference in the two groups. CK-MB, cTnI, NT-proBNP and complication rate were lower in the experimental group than those in the control group (P＜0.05). The ventilation time, ICU stay time and hospitalization time after operation were significantly shortened in the experimental group (P＜0.05). The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) were significantly improved after 1 month, 3 months, and 6 months after operation. Conclusion Coronary artery shunt can significantly reduce myocardial ischemic injury in off-pump coronary artery bypass grafting, and has significant clinical effect on reducing the incidence of perioperative acute myocardial infarction and complication rate. It also has significant clinical effect on the protecting cardiac function and shortening the postoperative recovery time.