Aim Based on the result of coronary angiography, to explore the effect of thermal texture mapping (TTM) technology screening coronary heart disease (CHD). Methods 190 cases of suspected CHD patients were enrolled as the research object. The clinical data, electrocardiogram, echocardiography, TTM, and coronary angiography were finished according to standard methods. Results There were 172 cases of patients with angina symptoms, 88 cases with positive electrocardiogram (ECG) findings, and 16 cases with positive echocardiography findings. Coronary angiography showed that 130 patients with CHD; while TTM showed 150 cases with inadequate myocardial blood supply. Based on the result of coronary angiography, the sensitivity and specificity of TTM to diagnose CHD was 100%, 66.67%; the accuracy was 89.47%. Compared with the clinical symptoms, electrocardiogram and echocardiography, the sensitivity and accuracy of TTM were the highest among these four methods. Meanwhile, the severity of myocardial ischemia judged by TTM was accordant with the biggest coronary stenosis rate determined by using coronary angiography. Conclusion As a completely noninvasive examination, TTM not only has the sensitivity to detect CHD, but also can reflect the severity of coronary stenosis.