Aim To investigate the effectiveness of the same and different drug-eluting stent in the treatment of coronary drug-eluting stent restenosis. Methods PubMed, OVID, Embase, Cochrane Library, Wanfang Database, China Journal Full-text Database(CNKI), Chinese Biomedical Literature Database (CBM), VIP Database (VIP) were retrieved. The materials of the treatment in coronary drug-eluting stent restenosis with the same and different drug-eluting stent were collected,10 studies were withdrawed, including 1680 patients. The RevMan5.2 analysis software was used in systematic review. Control test database computer retrieval to 2015 October. Results The different drug-eluting stent treatment in coronary drug-eluting stent restenosis was found to reduce the odds of target lesion revascularization (OR＝0.3,5%CI was 0.55~0.96, P＝0.02) and major adverse cardiovascular events (OR＝0.2,5%CI was 0.54~0.96, P＝0.03). There was no difference between the two groups in rates of death (OR＝1.3,5%CI was 0.49~2.16, P＝0.95) or myocardial infarction (OR＝0.9,5%CI was 0.24~1.41, P＝0.23). Conclusion For patients with restenosis after drug-eluting stent implantation, different drug-eluting stents are more benefit than the same drug-eluting stent implantation.